Getting down to detail

Mechanotransduction: Getting Morphogenesis Down Pat

Embryonic morphogenesis requires the coordination of forces across multiple tissues and their associated extracellular matrices. A new study reports a mechanical feedback loop in the Caenorhabditis elegans embryo between muscle and epidermis that may provide a model for understanding how tissues coordinate morphogenetic events in the embryo.

Embryo morphogenesis: getting down to cells and molecules.

After the molecular cloning revolution in the 1980s, the field of developmental biology became focused on the regulation of gene expression as a framework for understanding the specification of cell fate. The advent of sequenced genomes and comprehensive microarrays has removed the last obstacle to cataloguing the molecules that orchestrate development, and one challenge for the future will be ...

Primary care research conducted in networks: getting down to business.

This seventh annual practice-based research theme issue of the Journal of the American Board of Family Medicine highlights primary care research conducted in practice-based research networks (PBRNs). The issue includes discussion of (1) theoretical and methodological research, (2) health care research (studies addressing primary care processes), (3) clinical research (studies addressing the imp...

Work related upper limb disorders: getting down to specifics.

Getting down to Facts: School Finance and Governance in California

The purpose of this unprecedented project is to describe California’s school finance and governance systems, identify aspects of those systems that hinder the effective use of resources, and estimate costs of achieving a range of student outcome goals. The project is not designed to advance specific policy recommendations, but rather aims to provide a common factual ground to promote informed c...